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Carl Zeiss
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PerSeptive Biosystems Inc
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Ardigen S.A
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PerSeptive Biosystems Inc
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AstraZeneca ltd
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PerSeptive Biosystems Inc
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PrimerDesign Inc
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RStudio
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TriNetX Inc
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DOSECC Exploration Services LLC
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PerSeptive Biosystems Inc
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KNIME GmbH
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Image Search Results
Journal: STAR Protocols
Article Title: Protocol for image registration of correlative soft X-ray tomography and super-resolution structured illumination microscopy images
doi: 10.1016/j.xpro.2021.100529
Figure Lengend Snippet: Data sets a user is likely to have available for 3D SIM-SXT data registration (required files are denoted with ∗)
Article Snippet: VLM BF , White light image , cryoTXM ,
Techniques: Software, Fluorescence
Journal: bioRxiv
Article Title: A Framework for Autonomous AI-Driven Drug Discovery
doi: 10.1101/2024.12.17.629024
Figure Lengend Snippet: A) Selection of a cluster of 10 compounds with cell painting profiles most similar to Vorinostat by UMAP analysis using the Ardigen phenAID JUMP-CP Data Explorer ( https://phenaid.ardigen.com/jumpcpexplorer/ ). The x and y axes represent the first two dimensions of the UMAP projection, respectively. B) Top ranked targets from a focal graph search with the Vorinostat cell painting cluster, including Vorinostat itself. SMILES of the compounds in the cluster are shown. C) Selected focal graph evidence paths connecting a member of the compound series to HDAC1. D) The full vorinostat focal graph (top) and a subgraph (below) showing only query compounds, similar compounds, and targets. The location of a cluster of top ranked HDACs are highlighted. E) Large Language Model (LLM) analysis of the focal graph search which highlights HDAC inhibition as the best-supported target hypothesis for this compound cluster. – Focal graphs were used in combination with Claude 3.5 Sonnet, a foundational LLM from Anthropic.
Article Snippet: We selected a cluster of 10 compounds with cell painting profiles most similar to the HDAC inhibitor vorinostat by UMAP analysis using the
Techniques: Selection, Inhibition